Imbalanced gut can damage your Arteries #cardiovasculardisease #cardiovascularhealth #heartdisease

Number of Indians losing their life to #cardiovascular #disease stands at 272 individuals per 1,00,000 population, way more than the global average of 235 per 1,00,000 population. Like cancer, cardiovascular disease is hard to detect/asymptomatic & no preventative solutions exist as of now. Most of the #healthcare practitioners & #cardiologists look at #Homocysteine levels to assess the risk of onset & progression of heart disease. High homocysteine leads to overexpression of Asymmetric dimethyl arginine(ADMA) which suppresses #nitricoxide (NO) production. Since NO regulates blood flow & is a vasodilator, functional loss of NO could trigger onset of cardiovascular disease. What exactly is homocysteine? It is a non essential sulfur containing amino acid. Your #gutbacteria could sense methionine in various foods & express a particular #gene that codes for protein that metabolize & synthesize methionine and homocysteine levels. If you are consuming high amounts of this #aminoacid or you lack certain enzymes that can metabolize methionine in the small intestine, it could land up in your gut & specific #microbes could secrete homocysteine. However this should not be a problem since, homocysteine could be recycled back into cystathionine by cystathionine synthase which needs #vitaminB6 as a cofactor or into methionine which needs methionine synthase which needs #VitaminB12 a co-factor. If your blood work shows high homocysteine levels, your healthcare practitioner may recommend B Vitamin Supplements- Vitamin B6 or Vitamin B12. But is this the real solution ? If this would have been the case, the incidence of cardiovascular disease would have been reduced? It is no brainer that our body cannot metabolize B Vitamins & needs help from the gut microbiome to synthesize B Vitamins. If your gut microbiome is imbalanced, you may have B Vitamin deficiency & no matter how many supplements you take, your body will not get Vitamin B6 or Vitamin B12. If you really want to fix your cardiovascular health, focus on promoting gut microbial beneficial functions & eliminating instances of gut dysbiosis. We at #Genefitletics measure & quantify your gut microbiome functions to predict the onset of cardiovascular disease & provide interventions that can suppress pro-inflammatory activities & promote beneficial activities to improve your cardiovascular health. More details here: www.genefitletics.com Citations www.pnas.org/doi/10.1073/pnas.0607965104 pubmed.ncbi.nlm.nih.gov/11714652/ #heartdisease #heartattack #heartdiseaseawareness #hearthealth #metabolichealth #type2diabetes #coronaryarterydisease #cardiology #cardiologist #highbloodpressure #lowbloodpressure #hypertensionawareness #hypertension #cardiovasculardisease#heartcondition #healthhack #heartpalpitations #heartconditions #cholesterol #lowcarbdiet #lowcholesterol #highcholesterol #statin #healthtips #heartpatients #heartsurgerysurvivor