Bryan Johnson

Massive blood draw today:

> decoding 1 million immune cells
> identifying the rogue clones attacking my stomach
> causing the autoimmune gastritis

This is incredible technology.

Think of your immune cells as trillions of soldiers. Each carries a unique key designed to unlock and destroy a specific threat, like a virus or bacteria.

A standard blood test allows you to see how many soldiers you have, but not their keys. Sequencing 1 million individual immune cells allows us to read the exact pattern of the teeth on every single key.

This is important for my autoimmune gastritis (AIG) because a specific platoon of rogue soldiers has developed keys that unlock an attack on my stomach lining.

Right now, we don’t know who they are. This test will inform us of which soldiers have gone rogue and are attacking me from within.

Once we know soldier and key, we know what therapy path to pursue to shut them down.

Other makers in this blood draw:

Ferritin, Soluble Transferrin Receptor, Iron and TIBC, Transferrin Saturation, Erythropoietin (EPO), Reticulocyte Count, CBC With Differential/Platelet, Phosphorus, Comprehensive Metabolic Panel (14), Antiparietal Cell Antibody, Intrinsic Factor Abs, Gastrin, Chromogranin A, Celiac Ab tTG IgA w/Rflx, IL-2 Receptor Alpha, T- and B-Lymphocyte/Nat Killer, Complement C3, Complement C4, Tumor Necrosis Factor-Alpha, Interleukin-6, HLA DRB1/3/4/5/DQB1, Cardiometabolic Report, Total Glutathione, Selenium, Coenzyme Q10, Oxidized LDL, Essential Fatty Acid Profile, Lp-PLA2 Activity, Myeloperoxidase (MPO), Vitamin D 25-Hydroxy, Magnesium, Copper, Zinc, Vitamin B12, Methylmalonic Acid, Folate, Hemoglobin A1c, GlycA, Fructosamine, C-Reactive Protein Cardiac, NT-proBNP, Lipid Panel, Apolipoprotein A-1, Apolipoprotein B, NMR LipoProfile, Lipoprotein (a), p-tau217, S-100B Protein, Neurofilament Light Chain, Glial Fibrillary Acid Protein

1 day ago | [YT] | 1,854

Bryan Johnson

breakfast

red lentils, carrots, onion, celery, vegetable broth, mushrooms, parsley, oregano, garlic, cauliflower, arugula, parsley, cilantro, extra virgin olive oil, red wine vinegar, red chili pepper, balsamic reduction, sesame seeds as garnish

3 days ago | [YT] | 4,810

Bryan Johnson

Kate just called me…she apparently bombed the biggest interview of her life.

The WSJ has the exclusive to profile her. The interest in our female health protocol is a powder keg of energy. Every major publication has reached out.

In her typical neurodivergent fashion, Kate prepared a game show on a whiteboard to explain who she is. Apparently the reporter wasn’t that into it? Like being on stage with blank faces staring back.

I told her to not sweat it.

It’s her first go at this and this kind of outcome is inevitable. No need to rerun the interview 1,000 times in her head. She meets with the journalist again on Wednesday.

What advice would you offer up?

4 days ago | [YT] | 2,510

Bryan Johnson

Adult rights may be significantly curtailed in the future.

Teenagers rights are limited because relative to adults, their decision abilities are seen as inferior. If teenagers were the most cognitively advanced people on earth, they'd be in charge because of their relative superiority.

Rights follow from relative competence.

As AI scales, this same calculus will inevitably apply to adults.

Humans drive cars today because of their relative competence superiority. Once autonomous systems prove statistically superior, human driving will become unacceptable as a public safety hazard.

AI will manifest in similar ways across society, demonstrating superior judgment in law, medicine, finance, governance and beyond. I can also imagine individuals and companies willfully opting into outsourcing critical functions.

I'm not saying I want this world or that I think it's inevitable, only this is directionally where the patterns point if I follow the lines, and only if competence is the criteria for determination.

Of course, with the emergent complexity of AI it's impossible to know. And the guessing often says more about the guesser than the future itself.

4 days ago | [YT] | 1,386

Bryan Johnson

Who would you trust to run the world?

5 days ago | [YT] | 1,462

Bryan Johnson

We fill our days mostly on things that are trivial next to what we ultimately care about. We know, deep down, however, that in the noise of it all, health is easily forgotten until it’s the only thing that matters.

We spend a fraction of our lives truly sober to the preciousness of life. We feel it when someone we love dies, when a child is born, when we come close to death ourselves, or when a diagnosis marks our limit. In those moments, we are sobered, and the rarity of it all becomes self evident. Imagine the existence we’d build together if that clarity didn’t fade.

I wish all of you the very best. Care for yourself, care for others, care for the planet and care for our animal friends. Care for life as it’s the most precious gift there is.

5 days ago | [YT] | 3,686

Bryan Johnson

If you're under 55 and not healthly, read this:

People mistakenly think they can abuse their body when young and bounce back.

This study found that when your biological age is older than your chronological age, your risk of early cancer increases.

> for example, if you're 25 but your biological age is 35, you are at increased disease risk, not just someday, but before the age 55.

> for the widest age gaps, risk ran up to 57% higher for lung, 31% uterine, 17% GI

> this study used basic blood markers for 2 of the 3 tests to determine biological age

> people are getting older faster. People born 1965 to 1974 carried an age gap about 0.23 standard deviations larger than those born 1950 to 1954.

> counterintuitively, after the age of 55, the increased disease risk effect goes away

> so the risk is in the young

1 week ago | [YT] | 1,950

Bryan Johnson

Cancer runs in my family and about 5-10% of cancer is inherited. So I did a blood test that looked at 71 genes for inherited cancer risk.

All came back negative. I feel lucky.

You can sleep, exercise and eat right for decades, and one late cancer can do you in. Cancer is the second leading cause of death in the US, the first for anyone under 85. More than 1 in 3 of us will be diagnosed. A cancer death costs nearly 15 years of life, on average.

You want to catch cancer early. Breast cancer has a 5 year survival near 100% but caught late, survival drops to about 34%. Colon cancer: 91% versus 16%.

A genetic risk panel won't tell you if you have cancer. It tells you whether you were born holding a bad card, so you can watch the right things, sooner.

So I ran a combined DNA + RNA Panel covering 71 genes tied to inherited cancer risk, with RNA analysis on most. They cover the big hereditary pathways. DNA repair (BRCA1, BRCA2, ATM). Lynch syndrome (MLH1, MSH2). The classic tumor suppressors (TP53, APC, PTEN). The endocrine genes (RET, VHL, MEN1).

DNA shows the spelling of a gene. RNA shows what the cell actually builds from it. Up to 1 in 4 cancer-gene variants are predicted to disrupt splicing, the RNA edit that makes a working protein, and DNA alone often can't tell whether it matters, so it gets flagged "uncertain." Reading the RNA settles a lot of those, and catches broken variants DNA-only tests miss.

My result came back with no pathogenic variants in any of the tested genes, so it looks like I was born lucky.

This doesn't mean it clears cancer risk and it says nothing about the 90 to 95% of cancers that aren't inherited or influenced over a lifetime from age, environment, and luck.

Cancer surveillance is among the least glamorous parts of a longevity stack. It's also the most underrated.

The name of this test is Invitae Multi-Cancer Panel.

1 week ago | [YT] | 2,142

Bryan Johnson

I promise you that if you build your life around sleep, everything you care about will get better.

High quality sleep is like a daily dose of the world’s best longevity drug.

Sleep is key for...

+ will power
+ self control
+ sex
+ mood
+ recovery
+ focus
+ appearance
+ work
+ life

My sleep data last night

+ 4+ hr restorative
+ 53% total sleep restorative
+ resting heart rate 42 (elite athlete)
+ no sleep stress
+ no wake events
+ asleep in 2 min

It feels incredible. Gives me the powers of stamina, focus, motivation, discipline and love.

For fun, I made a sleep facts nutrition panel.

The sleep crash course:

1. Final food 4 hours before bed
2. Screens off 60 min before bed
3. Same bed time every single day
4. Light in eyes in am
5. Exercise daily, even if for 20 min

Here’s the key: make these habits non-negotiable in your life.

Build your life around sleep and I promise everything you care about will get better.

1 week ago | [YT] | 3,240

Bryan Johnson

Some of us will live forever.

And if you’re reading this, that may or may not be you.

I am so bullish on this that I just renamed my company to Immortals.

Below:
+ why I think this
+ early signs of success
+ how to increase your odds

Yes, I know this sounds crazy.

Immortality has been an ambition for humanity since the beginning of recorded history.

The immortality I’m referring to is specific: increases in life expectancy will outpace the rate of aging. Meaning, we will no longer, by default, expect to die of natural causes.

I believe this for three reasons.

#1: Immortality already exists

Biology can reverse some features of aging, and in a handful of organisms escape it almost entirely. For example, a sperm and an egg from two people in their 30s carry the legacy of bodies that have aged for decades (the egg in particular has been arrested inside the mother since before she herself was born), yet they combine to produce an embryo that resets the aging clock to zero.

The immortal jellyfish goes further and resets itself within one lifetime, reverting its adult cells to an earlier stage through transdifferentiation and starting its life cycle again. And in the lab, scientists have begun doing this deliberately, making induced pluripotent stem cells (iPSCs) from mature adult cells such as skin fibroblasts, and using partial cellular reprogramming to turn the clock back in the tissues of living animals.

#2: AI offers new potentials

Biology is a hard problem. For most of history that complexity was beyond native human capacity. AI was made for this complexity. The clearest demonstration so far is protein folding. Predicting the three-dimensional shape a protein folds was an unsolved problem for roughly fifty years, and it mattered because a protein's shape determines what it does in the body.

DeepMind's AlphaFold2 effectively solved it in 2020, reaching a median accuracy of 92.4 out of 100, a level long thought to require the slow, painstaking work of crystallizing a protein and solving its structure by X-ray crystallography. It then released predicted structures for over 200 million proteins, nearly the entire catalogued protein universe, in a fraction of the time anyone expected.

#3: Early signs are encouraging

These aspirations are not imaginative. With the current tools in biotech Sid Sijbrandij, the co-founder of GitLab, was diagnosed with an aggressive bone cancer, osteosarcoma in his vertebrae. He treated his own disease like an engineering problem, he used AI to help direct several experimental, personalized therapies in parallel and drove the cancer into remission after standard medicine had given up. Around the same time, an Australian named Paul Conyngham, with no medical or biology background, did something similar for his dog. He used AI to help design a personalized mRNA vaccine targeting the specific mutations in his dog's tumor, and after it was given alongside another immunotherapy and within a few months the main tumor had shrunk by roughly three-quarters.

How to increase your odds…

I. Don’t die in the meantime

We don’t know when these longevity therapies will become available. Your goal is to be around when they come out. Buy yourself as much time as possible by looking after your body to the best of our scientific knowledge. Good diet, sleep, exercise will get you 80% of the results.

II. Find your achilles

Longevity therapies will likely be outcome specific. Individual specific drugs/therapies that target specific things like…

> prevent and remove arterial plaque
> prevent and reverse neurodegeneration
> specifically target and eliminate cancers, or pre cancerous legions
> prevent frailty and muscle loss, and regain muscle mass, strength and, bone density
> reverse skin aging
> rejuvenate eye health
> restore lost hearing
> etc

We don’t know what therapies will be available first. Your goal is to find what your body is struggling with most and keep that problem at-bay until a therapy is available that can fully cure or reverse it.

For example, do you struggle with cholesterol? Blood glucose control? Cognitive decline? Find your achilles heel and reduce your risk systematically.

III. Invest in the future

There are three macro trends happening on planet earth right now, and the people who bet on these areas have the highest risk + reward.

> AI
> Immortality
> Energy

As we know, power comes in many forms: money, social, political, health, etc. Those that can collect power in these fields will have the greatest chance of positioning themselves in the Immortal future.

With time, Immortal therapies will become broadly available.

If you’re reading this: don’t waste your chances by burning down your life points on a yolo-like mentality. Grind culture, addiction, social media pollution, fast food, porn, alcohol, these are all corporations turning your life into their profit. This is the Die Economy.

My company Immortals has the sole objective of turning your time, attention, and life into more healthy, functional, and prosperous minutes, days, and years. The Don’t Die Economy.

Good luck.

1 week ago | [YT] | 3,202