Physionic

*Note:* I received a critique through my critique form (found under all the videos) where a person pointed out a variety of points they disagreed with in my analysis called 'Multiple Organs suffer from ‘Ferro-Aging’ - One Vitamin Stops It'. I thought some of their points were good ones, so I wanted to release three notes on the analysis.

Note 1: The blood Fe2+ (ferrous iron) measurements were only measured in a Chinese cohort, so it's possible that data may not apply to other areas of the world or other distinct populations.

Note 2: The data included both men and women, but the data was combined, so we can't tease out if the effects are different between men and women.

Note 3: I pointed out that the study, while compelling using data from a variety of sources, is not translatable to humans, yet. However, let me re-iterate that the study should not be taken as evidence to stop iron supplements (this was an especially troubling concern for the critiquer). Many people suffer from iron deficiency and there are consequences from iron deficiency, so at no point should we be A) acting on, or B) translating the data to, 'lowest possible iron is best'. Aside from the fact that the study is not yet ready to be translated to humans, or the fact that the study wasn't arguing for the elimination of iron, the study was mainly focused on intracellular iron, which is more complex than just blood iron measurements. If a person is low on iron, that should always take priority and should be addressed, as needed.


These points have already been added to the video, just reiterating it here.


Looking forward to tomorrow's video - it's on peptides, and then Saturday we're getting into... 'Sardine Fasting'! See you then.

3 weeks ago | [YT] | 749

Physionic

No Centrifuge episode this week.

I've already recorded the next two, but it was too tight a deadline to get them edited, so The Centrifuge comes back next Saturday. Then, I may need to take another week, because A) I've been dying to get into a huge analysis on protein and atherosclerosis (13 studies!), and B) I'm considering an upcoming Centrifuge episode on Dr. Huberman's interview with Dr. Robert Lustig, which is a 3 hour podcast... so, yea... a ton of work.

If you have suggestions on upcoming episodes, feel free to post them below. Have a great weekend!

4 months ago | [YT] | 276

Physionic

Are you tired of this, too?

Are you tired of listening to health podcasts and not knowing if the guest is talking real data driven perspective or if they're pulling BS out of their rear-end?

I am. I've stopped listening to podcasts, because I'm getting frustrated listening. Or, at least, I stopped listening until now...

I'm starting a new show on the channel - it's called 'The Centrifuge', where we spin out the BS from the science (lab nerds will especially appreciate the name, I think). Essentially, I'm going to go through the majority of popular podcast episodes (Attia, Huberman, Jay Shetty, Mel Robbins, you name it), and across multiple episodes, I will dissect the claims - both wild and fair - and add scientific references, context, and application to the words uttered. No more guesswork.

The episodes will *not* interfere or replace any of the other original videos I release - they are 'in addition to' the regular scheduled programming. This is a trial run, but I feel passionate about this, because: I'm tired of the pseudoscientific BS. So, we'll see if it sticks around (it takes me weeks of work for each podcast episode), but I do think it'll help you identify what claims have at least some scientific basis and which do not.

I've recorded 3 episodes already - the first episode releases THIS SATURDAY (12/13) and begins with a two part on a prominent doctor. I'm excited - I hope it helps!

(Also, tomorrow's video is going to be a sweet one... pun intended.)

Nic

5 months ago | [YT] | 1,448

Physionic

Hey all, I was interviewed/had a wonderful discussion with Dr. Nick Norwitz over on his channel on two topics you might find interesting - especially the seed oil discussion, but if you've seen my recent coverage on FGF21, you'll prefer the 'Sugar Diet' video. Both are linked below.

Seed Oils: https://youtu.be/VDJGCw-enhI?si=27ooU...

'Sugar Diet': https://youtu.be/YPGBQPqvwDg?si=ODtFz...

Hope you enjoy!

9 months ago | [YT] | 285

Physionic

Hi all - I unlisted my LMHR video, because I received some excellent critiques and was made aware of some additional information I wasn't aware of during the first recording. So, I'm going to address those critiques and upload a new video, but I'll include the original video in the description of the new video for those that still want to see what I originally said.

I appreciate the respectful, critical feedback, as always.

1 year ago | [YT] | 1,378

Physionic

After much deliberation with family and friends, I have made the difficult decision...

...to wear a belt.

IYKYK. 😉

1 year ago | [YT] | 441

Physionic

Hi all - I'm doing a promised live session with the Physionic Community this Saturday. I'll be covering my personal research and just generally hanging out. It's free, but you must be part of the free Physionic Community (bit.ly/PhysionicCommunity2) or on the email list (bit.ly/2AXIzK6) to join.

Neither the live session nor the recording will be on YouTube, so be sure to join via either method above, if you can!

Should be a fun time - hope you can make it,
Nic

1 year ago | [YT] | 167

Physionic

C15 Fats. I had to break it into 2 videos, because I had a lot to say. Releases next week (barring any complications with editing).

For reference, I started reading the studies on the topic over 2 weeks ago - it takes a long time to make sure the information is accurate and fair, but I'm very much looking forward to discussing with you - these were fun videos...

See you on Monday (and have a great weekend!),
Nic

1 year ago | [YT] | 752

Physionic

Hi all - I've looked over the literature for studies on canola oil and inflammation (in humans) and found 8 studies (see below). I'm wondering, since seed oils and canola oil are such polarizing topics and *surely* people have presented evidence for their stances, if you know of any other studies (in humans) that look at canola oil/rapeseed oil and inflammation (pro-inflammatory, anti-inflammatory, etc.) that I have missed, could you post them below?

I'd like to review all the studies I can so it doesn't seem like I'm cherry picking. Please post any below - they can be associative, but preferably RCTs (in humans).

Studies I have already:
1. Nikooyeh B, Zargaraan A, Ebrahimof S, et al. Daily consumption of γ-oryzanol-fortified canola oil, compared with unfortified canola and sunflower oils, resulted in a better improvement of certain cardiometabolic biomarkers of adult subjects with type 2 diabetes: a randomized controlled clinical trial. Eur J Med Res. 2023;28(1):416. Published 2023 Oct 10. doi:10.1186/s40001-023-01409-8

2. Morvaridi M, Jafarirad S, Seyedian SS, Alavinejad P, Cheraghian B. The effects of extra virgin olive oil and canola oil on inflammatory markers and gastrointestinal symptoms in patients with ulcerative colitis. Eur J Clin Nutr. 2020;74(6):891-899. doi:10.1038/s41430-019-0549-z

3. Khandouzi N, Zahedmehr A, Nasrollahzadeh J. Effects of canola or olive oil on plasma lipids, lipoprotein-associated phospholipase A2 and inflammatory cytokines in patients referred for coronary angiography. Lipids Health Dis. 2020;19(1):183. Published 2020 Aug 14. doi:10.1186/s12944-020-01362-z

4. Atefi M, Pishdad GR, Faghih S. The effects of canola and olive oils on insulin resistance, inflammation and oxidative stress in women with type 2 diabetes: a randomized and controlled trial. J Diabetes Metab Disord. 2018;17(2):85-91. Published 2018 May 23. doi:10.1007/s40200-018-0343-9

5. Manning PJ, Sutherland WH, McGrath MM, de Jong SA, Walker RJ, Williams MJ. Postprandial cytokine concentrations and meal composition in obese and lean women. Obesity (Silver Spring). 2008;16(9):2046-2052. doi:10.1038/oby.2008.334

6. Gillingham LG, Gustafson JA, Han SY, Jassal DS, Jones PJ. High-oleic rapeseed (canola) and flaxseed oils modulate serum lipids and inflammatory biomarkers in hypercholesterolaemic subjects. Br J Nutr. 2011;105(3):417-427. doi:10.1017/S0007114510003697

7. Liu X, Kris-Etherton PM, West SG, et al. Effects of canola and high-oleic-acid canola oils on abdominal fat mass in individuals with central obesity. Obesity (Silver Spring). 2016;24(11):2261-2268. doi:10.1002/oby.21584

8. Perez-Herrera A, Delgado-Lista J, Torres-Sanchez LA, et al. The postprandial inflammatory response after ingestion of heated oils in obese persons is reduced by the presence of phenol compounds. Mol Nutr Food Res. 2012;56(3):510-514. doi:10.1002/mnfr.201100533

(Human studies only, did I mention that already? :) )

Thanks!

1 year ago (edited) | [YT] | 860

Physionic

Video take-down:
Study Analysis: GLP-1RAs on Weight Loss

Hello - If you aren't aware, under all my videos I have a 'Critique my Work' link so people can point out where I've made mistakes. Recently, someone (Dr. Mills) wrote in that one of the meta-analyses I covered in my GLP1RA study analysis had far more flaws in it than I presented. After a lengthy discussion with them, it seemed clear that the meta-analysis had more flaws in it than justifiable for a simple 'Amendment' under the video. As such, I've taken the video down.

Ultimately, the conclusion of the video likely stands (i.e. GLP1RAs cause weight loss), even in the face of this poor data, but it's still better to take down the video than keep it up with the assumption the data presented was high quality (because the end result isn't all that matters - learning how we get to that conclusion is also extremely valuable). Anyway, I'm thrilled to have had the opportunity to learn from an expert in meta-analysis like Dr. Mills, and expect to continue to improve to make sure I don't miss any other flaws in these types of studies.

Anyway, thank you to Dr. Kerry Mills for the corrections, and I hope you all have a great day.

Nic

1 year ago | [YT] | 1,249