Precision Analytical, Creators of the DUTCH Test

In this episode, Dr. Mark Holthouse joins Dr. Jaclyn Smeaton and DUTCH founder Mark Newman to discuss a recent peer-reviewed publication from Precision Analytical, Inc. in Frontiers on hormone monitoring methods, including saliva testing, for testosterone hormone therapy.

Their discussion also covers:
- How saliva values spike when measuring transdermal testosterone or estradiol and the clinical impact
- Dosing using saliva values and how it can cause overdosing or underdosing
- The complexity of estradiol monitoring
- The importance of relying on clinical evidence over established practice
- Serum and urine testing’s clinical validity and how test values align with clinical outcomes

Check it out below! ✨

22 hours ago | [YT] | 0

Precision Analytical, Creators of the DUTCH Test

In this episode, Dr. Jaclyn Smeaton discusses Hashimoto’s thyroiditis with Inna Topiler, a board-certified clinical nutritionist who shares her personal experience and health journey with Hashimoto’s.

Their discussion also covers:
- Why standard thyroid testing is insufficient
- The four main triggers of immune confusion in Hashimoto’s, including stress, infections, toxins, and food sensitivities
- The impact of dysregulated cortisol on thyroid function
- How cortisol patterns on the DUTCH Test can be informative for Hashimoto’s patients
- Practical and accessible stress management tips

Check it out below! 👇

1 week ago | [YT] | 0

Precision Analytical, Creators of the DUTCH Test

Join us for this episode with Dr. Jenn Simmons, an integrative breast surgeon and oncologist, alongside host Dr. Jaclyn Smeaton and DUTCH founder Mark Newman. This conversation deepens the discussion from a previous episode on hormones and breast cancer risk, challenging widely held clinical assumptions rooted in the Women's Health Initiative (WHI) study.

This episode also explores:
- The critical distinction between progestins and progesterone
- The role of metabolic dysfunction in cancer development
- Breast cancer as a disease of hormone deficiency, particularly progesterone deficiency, rather than hormone excess
- The impact of estrogen metabolism, especially the 4-hydroxy pathway, and how the DUTCH Test can provide insight into these pathways
- Individualized hormone therapy for breast cancer survivors

Check it out below! 🤩

2 weeks ago | [YT] | 1

Precision Analytical, Creators of the DUTCH Test

In this episode, Dr. Asare Christian and Dr. Jaclyn Smeaton discuss female longevity and health span. Dr. Christian brings his unique perspective as a former pain specialist who discovered that many of the chronic conditions he was treating were rooted in hormone imbalance.

This episode also highlights:
- Three main factors that can contribute to women living longer
- The protective qualities of estrogen as well as the effects of its decline during perimenopause
- The importance of testing early and getting baseline hormone levels before symptoms appear
- How the DUTCH Test provides a picture of hormone metabolism, leading to clarity around estrogen metabolites, the HPA axis, and more
- Treating the hormonal root cause rather than prescribing medications for each symptom

Check it out below! 👇

3 weeks ago | [YT] | 0

Precision Analytical, Creators of the DUTCH Test

Oxidative stress plays a central role in hormone balance, inflammation, immunity, and overall metabolic health, and it’s a pattern many providers see reflected in patient results every day.

In this webinar, Dr. Lacy Campbell, ND, breaks down how reactive oxygen species (ROS) function as essential signaling molecules, what drives them out of balance, and how hormonal transitions—from puberty to perimenopause—shape redox status and immune function.

Using a clinically practical, integrative lens, Dr. Campbell explores:
- How ROS are generated, regulated, and measured
- The impact of stress, sleep, environmental exposures, and lifestyle patterns on oxidative load
- How hormonal shifts influence inflammation and immune resilience across the lifespan
- The connection between oxidative stress and chronic disease, aging, and symptom progression
- Evidence‑informed strategies to support redox balance through nutrition, lifestyle, and targeted supplementation
- A real‑world case study of perimenopause‑related frozen shoulder and the role of hormone therapy in recovery

Check it out below! ✨

3 weeks ago | [YT] | 1

Precision Analytical, Creators of the DUTCH Test

n this episode, Dr. Jaclyn Smeaton and Dr. Donielle Wilson (‪‪@ClearHPVnow‬) discuss Dr. Donielle’s clinical philosophy, research findings, and personal journey around understanding and treating stress.

Their discussion also covers:
- The stress response and how it’s highly individualized, shaped by genetics, and impacted by prior stress exposure
- How standard cortisol testing misses most of the cortisol picture
- Chronic stress and its cascade to multiple body systems, including the reproductive system in women
- The five clinical stress patterns practitioners should be aware of
- Small, consistent actions toward stress recovery, like mindfulness and deep breathing, can make a big difference

Watch below! 👇

4 weeks ago | [YT] | 0

Precision Analytical, Creators of the DUTCH Test

In this insightful episode, ‪@Dr.HeatherSandisonND‬ ‬and Dr. Jaclyn Smeaton discuss the root causes of cognitive decline and Alzheimer's, how a naturopathic approach differs from conventional medicine, and practical strategies for brain health at any age.

This episode also highlights:
- The six drivers of cognitive decline
- The impact of hormones, especially the steep drop in estrogen at menopause
- How infections like Lyme disease, shingles, and COVID-19 can be linked to cognitive decline
- Tips for early intervention, including the importance of sleep hygiene along with diet, exercise, and stress management
- Using genetics to inform and optimize early intervention strategies

Watch the new episode below! 👇

1 month ago | [YT] | 1

Precision Analytical, Creators of the DUTCH Test

In this episode, Dr. Jaclyn Smeaton and DUTCH Founder Mark Newman discuss a case study published in Integrative Medicine: A Clinician’s Journal in which Mark himself was the patient. The case covers the step-by-step hormonal and metabolic effects of using HCG to boost endogenous testosterone, revealing how increasing testosterone can cascade into elevated estrogen, impaired estrogen clearance, and strained methylation capacity.

Their conversation also highlights:
- The benefits of combining serum testing and DUTCH testing to monitor dosing as well as metabolism, clearance, and methylation
- How methylation is affected by raising testosterone
- The value of tracking step-by-step supplementation plans with repeated testing
- The importance of baseline testing before beginning testosterone therapy
- An upcoming research publication that compares hormone testing methods for testosterone monitoring

Check it out below!

1 month ago | [YT] | 1

Precision Analytical, Creators of the DUTCH Test

Join Dr. Allison Smith and Dr. Jaclyn Smeaton for this episode as they share expert insights into how hormones, the HPA axis, and lifestyle factors influence immune health, injury risk, sleep, and overall well-being during perimenopause and menopause. 

Dr. Smeaton and Dr. Smith also discuss:
- The relationship between hormonal changes, stress, and inflammation
- How cortisol and estrogen can impact sleep quality and inflammation in perimenopausal women
- Patterns seen on DUTCH tests indicating inflammation, immune overactivation, or hormone resistance
- Inflammation markers like quinolinate and melatonin and how they can help assess immune health
- How hormonal fluctuations alter immune responses, leading to symptoms like itchy ears, joint pain, and autoimmunity

Check it out below! 🤩

1 month ago | [YT] | 5

Precision Analytical, Creators of the DUTCH Test

In this episode, Dr. Alan Bauman and Dr. Jaclyn Smeaton discuss the complexities of hair restoration, particularly focusing on menopausal hair loss in women.

This discussion also explores:
- Understanding female pattern hair loss
- Emotional and hormonal factors affecting hair health
- Innovative therapies that can aid in hair restoration, including stem cell therapy
- The importance of nutrition and stress management in hair health
- How personalized treatment plans can help effectively address hair loss in women

Check it out below! 👇

2 months ago | [YT] | 0