Dr. Gabrielle Lyon is a Board-Certified Family Physician and the Founder of Muscle-Centric Medicine®.
Two-Time New York Times Bestselling Author.
Disclaimer: The Dr. Gabrielle Lyon Podcast and YouTube are for general information purposes only and do not constitute the practice of medicine, nursing, or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast, YouTube, or materials linked from this podcast or YouTube is at the user's own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professional for any such conditions.
Dr. Gabrielle Lyon
In this episode, I sat down with Dr. Kevin Maki, Former President of the National Lipid Association, to discuss why reducing saturated fat to 10% is an incomplete strategy for most people and why LDL cholesterol, while critical, is just one of many risk factors clinicians must assess. The evidence is more nuanced than the guidelines suggest, and this conversation explains exactly why.
WATCH HERE: bit.ly/4nS0rMo
1 day ago (edited) | [YT] | 124
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Dr. Gabrielle Lyon
What if the GLP-1 medication you are on is working exactly as designed, and still leaving your body worse off than when you started?
In this new episode with Dr. Michelle Pearlman, we discuss:
- Why 25 to 40% of weight lost on GLP-1s is lean tissue, not just fat
- How delayed gastric emptying affects everything from reflux to drug absorption to birth control efficacy
- Why skipping protein guidance and resistance training is not a side effect. It is a clinical failure
- What the combination of GLP-1 therapy and hormone replacement is doing for body composition in midlife women
- Why hand grip strength should be standard in every clinical visit, not just blood pressure
Weight loss commerce is not medicine. This episode is the conversation your provider should be having with you.
What is one question you wish your doctor would ask at every visit?
WATCH HERE: bit.ly/4uWMm2q
1 week ago (edited) | [YT] | 180
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Dr. Gabrielle Lyon
Are you treating pelvic pain without understanding the cause?
Most people assume pelvic or testicular pain is structural. But in many cases, it is neuropathic. In this discussion with Dr. Susan MacDonald, we highlight a major clinical issue. Patients are choosing extreme surgical options while nerve-focused procedures with strong success rates are underutilized.
This is not just about pain. It is about decision-making under uncertainty. Stress, lifestyle, and nervous system dysregulation can amplify symptoms. If you do not identify the root mechanism, you risk treating the symptom and not the problem.
WATCH HERE: bit.ly/3QO4exU
3 weeks ago (edited) | [YT] | 130
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Dr. Gabrielle Lyon
Strength is not one lift. It is the capacity you keep.
In this conversation, Mark Bell highlights something most people misunderstand.
Strength is not just your bench, squat, or deadlift. It’s your ability to produce force, move well, stay coordinated, and remain in control of your body.
These are the qualities that decline first.
And when they go, it’s not just performance that suffers. Your resilience, your independence, and your options start to narrow.
Train for the life you want to live, not just the numbers you can lift.
Watch here for the full episode: https://youtu.be/Pe11WYSS2lU
4 weeks ago (edited) | [YT] | 307
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Dr. Gabrielle Lyon
What if weight loss medications are not solving the real problem?
GLP one drugs are highly effective, yet behavior change remains the limiting factor. People still struggle with hunger, nutrition, and exercise even with pharmacological support.
This episode with Dr. Christle Guevarra explores the disconnect between medical treatment and sustainable habits.
Watch here for the full episode: bit.ly/3OSGO9S
1 month ago | [YT] | 215
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Dr. Gabrielle Lyon
What if the concept of how you should age is driving poor health decisions?
Training and nutrition must align with individual physiology, not unrealistic standards. Ignoring this increases the risk of injury and limits progress.
This episode with Dominique Sachse explores why understanding your "why" is critical for long-term strength and resilience.
Watch now.
1 month ago | [YT] | 329
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Dr. Gabrielle Lyon
What if avoiding fish during pregnancy is a mistake?
Omega 3 fatty acids, especially DHA, are essential for brain development, and early nutrition plays a direct role in shaping long term cognitive health.
In this episode, Tom Brenna and I discuss maternal nutrition, fat quality, and why this developmental window matters.
Episode out now.
1 month ago | [YT] | 154
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Dr. Gabrielle Lyon
Misinformation is not always obvious. In many cases, it is presented in a way that appears credible but lacks the rigor needed to support meaningful conclusions.
Yet most conversations still focus on what to believe, rather than how to evaluate what we are seeing.
In this episode, I sit down with Dr. David Allison, one of the leading voices in obesity and nutrition research, to discuss how to assess scientific evidence. We explore the difference between trusting science as a process versus trusting individual studies, why much of nutrition research can be misleading, and how to approach claims from research, media, and emerging technologies like AI.
Sometimes the question is not what information is available. It is how we determine what is reliable.
Listen to the full conversation.
1 month ago | [YT] | 162
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Dr. Gabrielle Lyon
Cognitive decline is not an inevitable part of aging. In many cases, it is influenced by modifiable factors that accumulate over time.
Yet most conversations still focus on treatment rather than prevention.
In this episode, I sit down with Dr. Tommy Wood, neuroscientist and author of The Stimulated Mind, to discuss what actually drives brain health across the lifespan. We explore how white matter changes develop, the role of ketones in supporting a metabolically compromised brain, and why social connection may be one of the most overlooked variables in cognitive aging.
Sometimes the question is not what happens when the brain declines. It is what we can do now to preserve it.
Listen to the full conversation.
2 months ago | [YT] | 258
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Dr. Gabrielle Lyon
Metabolic flexibility may be one of the most overlooked markers of long term health. Your body should be able to shift between burning carbohydrates and fat depending on the demand.
But many people lose that ability over time.
In this episode, I sit down with Dr. Martin Gibala to discuss the science of Fat Max, why mitochondrial quality matters for both performance and longevity, and how sprint interval training can stimulate mitochondrial adaptations comparable to traditional endurance training in far less time.
Sometimes the question isn’t how long you train. It’s how intensely you’re willing to push.
Episode out now.
2 months ago | [YT] | 293
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